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A double-stranded DNA virus of the Orthopoxvirus family, mpox (formerly monkeypox), continues to infect people daily, following the 2022 global outbreak.1 Two clades (clade 1 and clade 2) have been identified, with the 2022 outbreak caused by a subclade of clade 2, referred to as clade 2b.2 Comparatively, clade 1 leads to a more severe disease state and greater […]

Tomáš Hanke, HIVR4P 2021: T cell Vaccines for HIV-1 Infection (Part 1)

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Published Online: Mar 23rd 2021

We caught up with Tomáš Hanke (University of Oxford, Oxford, UK) to discuss T-cell vaccine strategies for the treatment of people with HIV-1 infection.

His abstract entitled: ‘Refocusing T cell responses with therapeutic vaccination strategies’ (SY09.03) was presented at the HIVR4P Virtual Conference 2021, 04 February 2021.

Part 2 of our discussion can be viewed here.

Questions:

  1. What is the rationale for developing T-cell vaccines for the treatment of people with HIV-1 infection? (0:19)
  2. What have been the greatest challenges to producing an effective and safe vaccine? (1:23)
  3. What vaccine strategies have proved most successful to date? (2:28)

Disclosures: Tomáš Hanke is a QA coinventor on a patent protecting the use of the conserved mosaic vaccines.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch.

Filmed in coverage of the HIVR4P Virtual Conference 2021. 

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