An Introduction to Sepsis
Sepsis is defined as life-threatening organ dysfunction, caused by a dysregulated host immune response to infection. Sepsis-related deaths represent around 20% of all global deaths. Early diagnosis and treatment are crucial to improving clinical outcomes. Machine-learning algorithms are being used to aid clinical decisions. Treatment involves antibiotics and supportive therapy, such as immunomodulators, vasopressors and fluid resuscitation. There have been few therapeutic developments in the last 20 years; however, nanoparticles have potential in both the detection and treatment of sepsis-related infections. Another focus of research is blood cell biomarkers; changes in CD52 and S100A9 are strong predictors of outcomes. The field of sepsis is highly diverse and it is a rapidly growing area of research and development.
Karin Thursky, ECCMID 2022: Challenges of sepsis and antimicrobial stewardship programmes in hospitals
Prof. Karin Thursky (National Centre for Antimicrobial Stewardship, Melbourne, Australia) discusses the challenges of sepsis and antimicrobial stewardship programmes in hospitals. Prof. Thursky is a recognised international expert on the design and implementation of antimicrobial stewardship programs, with expertise in the use of information technology for antimicrobial stewardship and more broadly in healthcare. The presentation […]
Karin Thursky, ECCMID 2022: Reconciling sepsis initiatives and antimicrobial stewardship programmes
Prof. Karin Thursky (National Centre for Antimicrobial Stewardship, Melbourne, Australia) discusses the management of sepsis in patients, recommendations that have been made for quality indicators for the use of antibiotics and adherence to these recommendations, and how to reconcile sepsis initiatives and antimicrobial stewardship programs in hospitals. Prof. Thursky is a recognised international expert on […]
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