An Introduction to Sepsis
Sepsis is defined as life-threatening organ dysfunction, caused by a dysregulated host immune response to infection. Sepsis-related deaths represent around 20% of all global deaths. Early diagnosis and treatment are crucial to improving clinical outcomes. Machine-learning algorithms are being used to aid clinical decisions. Treatment involves antibiotics and supportive therapy, such as immunomodulators, vasopressors and fluid resuscitation. There have been few therapeutic developments in the last 20 years; however, nanoparticles have potential in both the detection and treatment of sepsis-related infections. Another focus of research is blood cell biomarkers; changes in CD52 and S100A9 are strong predictors of outcomes. The field of sepsis is highly diverse and it is a rapidly growing area of research and development.
A personalized immunotherapeutic approach to the treatment of sepsis: Evangelos Giamarellos, ECCMID 2023
In recent years clinical trials with immunomodulators for sepsis have failed to make a significant impact. The PROVIDE clinical trial (NCT03332225) investigated whether a personalized immunotherapeutic approach targeting differences in immune dysregulation phenotypes in sepsis would improve outcomes. In this interview, we spoke with Editorial Board member Prof. Evangelos Giamarellos (ATTIKON University Hospital, Athens, Greece) to […]
NeoCHG: efficacy and safety of chlorhexidine gluconate skin application for sepsis in neonates: Michelle Clements, ECCMID 2023
Neonatal sepsis is often a result of pathogenic infection in a hospital setting and is a high risk for mortality especially in low and middle income countries. We caught up with Dr. Michelle Clements (University College London, London, UK) to discuss the aims, design and findings from their pilot study investigating the efficacy and safety […]
Karin Thursky, ECCMID 2022: Challenges of sepsis and antimicrobial stewardship programmes in hospitals
Prof. Karin Thursky (National Centre for Antimicrobial Stewardship, Melbourne, Australia) discusses the challenges of sepsis and antimicrobial stewardship programmes in hospitals. Prof. Thursky is a recognised international expert on the design and implementation of antimicrobial stewardship programs, with expertise in the use of information technology for antimicrobial stewardship and more broadly in healthcare. The presentation […]
Karin Thursky, ECCMID 2022: Reconciling sepsis initiatives and antimicrobial stewardship programmes
Prof. Karin Thursky (National Centre for Antimicrobial Stewardship, Melbourne, Australia) discusses the management of sepsis in patients, recommendations that have been made for quality indicators for the use of antibiotics and adherence to these recommendations, and how to reconcile sepsis initiatives and antimicrobial stewardship programs in hospitals. Prof. Thursky is a recognised international expert on […]
Journal articles and more to your inbox
Get the latest clinical insights from touchINFECTIOUS DISEASESSign me up!