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A double-stranded DNA virus of the Orthopoxvirus family, mpox (formerly monkeypox), continues to infect people daily, following the 2022 global outbreak.1 Two clades (clade 1 and clade 2) have been identified, with the 2022 outbreak caused by a subclade of clade 2, referred to as clade 2b.2 Comparatively, clade 1 leads to a more severe disease state and greater […]

Louis Picker, HIVR4P 2021: CMV-vector vaccines for HIV Prevention

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Published Online: Mar 23rd 2021

It was a pleasure to speak with Louis Picker (VGTI-Vaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, OR, USA) to discuss his work in CMV-vector vaccines for HIV prevention.

The abstract entitled: ‘CMV-vectored vaccines for HIV prevention’ (SY09.03) was presented at the HIVR4P Virtual Conference 2021, 04 February 2021.

Questions:

  1. Could you give us an overview of the current status of vaccine development for HIV and its unmet needs? (0:14)
  2. What is the rationale for using cytomegalovirus (CMV) as a vaccine vector for HIV? (0:29)
  3. What are the challenges in the development and use of CMV-vectored vaccines? (4:05)
  4. What preclinical and clinical evidence supports the use of CMV-vectored vaccines? (6:28)
  5. What safety concerns are associated with this approach? (8:25)

Disclosures: Louis Picker is the Founder of, and Consultant for, Vir Biotechnology, Inc., which is developing CMV-based vaccine vector for clinical use.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch.

Filmed as a highlight of HIVR4P Virtual 2021.

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