Hepatitis
An Introduction to Hepatitis
Hepatitis represents a substantial health burden worldwide; hepatitis B and hepatitis C combined are among the top four global infectious diseases in terms of mortality. The World Health Organization are aiming for a 90% reduction in hepatitis C by 2030. However, barriers exist, including genetic diversity of the virus, limited models for testing vaccines, and an incomplete understanding of protective immune responses. Recent vaccine research has focussed on adjuvant envelope or core protein and virus-vectored non-structural antigen vaccines. Novel serum markers of infection have enhanced diagnosis, disease staging and monitoring. There have also been advances in antiviral strategies for hepatitis C infection, with several drugs receiving regulatory approval in the past decade.