HIV-1 cure has been reported in two men with HIV-1 and malignancy following CCR5δ32 homozygous allogeneic adult stem cell transplantation. Prof. Yvonne Bryson (David Geffen School of Medicine, UCLA, and UCLA Mattel Children’s Hospital, Los Angeles, CA, USA) reports on a woman in ART-free HIV-1 remission for 14 months following CCR5∆32 homozygous cord blood and CD34-selected haploidentical stem cell transplant (haplo-cord SCT) for acute myeloid leukaemia.
The abstract entitled: ‘HIV-1 Remission with CCR5δ32δ32 Haplo-Cord Transplant in A US Woman: IMPAACT P1107’ (Abstract #65) was presented at the Conference on Retroviruses and Opportunistic Infections (CROI) 2022 (Virtual), 12-16 February 2022.
Questions:
- Could you give us a brief overview of the case of the woman who has achieved HIV remission after stem cell transplant? (0:09)
- What are the aims and design of the IMPAACT P1107 study? (1:43)
- What other study findings have been observed to date? (3:16)
- What are the implications of this case on HIV therapy? (4:08)
- What questions remain unanswered and what further research is planned? (5:17)
Disclosures: Prof. Yvonne Bryson has nothing to disclose in relation to this video interview.
Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch.
Filmed as a highlight of CROI 2022
