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Aqsa Jawaid Siddiqui, Aamir Sikandar Kazi, Ghina Shamim Shamsi

Tuberculous mastitis (TM) is a rare chronic granulomatous disease predominantly caused by Mycobacterium tuberculosis.1 TM accounts for less than 0.1% of all breast diseases worldwide, whereas it is more common in endemic regions (3–4.5%).2,3 TM is more prevalent in the reproductive age group, especially during the lactation period, when patients are more susceptible since the […]

David Lawrence, IAS 2021: Liposomal Amphotericin B Deoxycholate for the treatment of HIV-associated Cryptococcal Meningitis

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Published Online: Aug 17th 2021

We had the pleasure to meet with David Lawrence (London School of Hygiene and Tropical Medicine, London, UK) to discuss single high-dose liposomal amphotericin based regimen for treatment of HIV-associated Cryptococcal Meningitis.

The abstract entitled: ‘Single high-dose liposomal amphotericin based regimen for treatment of HIV-associated Cryptococcal Meningitis: results of the phase-3 Ambition-cm Randomised Trial’ was presented at IAS 2021 – the 11th International AIDS Society Conference on HIV Science (Virtual).

Questions:

  1. Could you tell us a little about HIV-associated cryptococcal meningitis (CM), and its health burden in sub-Saharan Africa? (0:20)
  2. What treatment options are recommended for CM and what are their limitations? (0:41)
  3. What is the rationale for the use of a single, high-dose of liposomal amphotericin B deoxycholate in this treatment setting? (2:08)

Disclosures: David Lawrence has nothing to disclose in relation to this video.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch.

Filmed in coverage of IAS 2021 Virtual.

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