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Viral Infections, HIV

Christoph Spinner, IAS 2021: Results from the DISCOVER Open Label Study

Published Online: August 5th 2021

We had the pleasure to meet with Christoph Spinner (University Hospital rechts der Isar, Technical University of Munich (TUM), Munich, Germany) to discuss the DISCOVER open label phase results.

The abstract entitled: ‘Outcomes of participants switching from F/TDF to F/TAF for PrEP: week 48 results from the DISCOVER open label phase’ was presented at IAS 2021 – the 11th International AIDS Society Conference on HIV Science (Virtual).

Questions:

  1. What is the rationale for the use of emtricitabine and tenofovir alafenamide rather than emtricitabine and tenofovir disoproxil fumarate in pre-exposure HIV prophylaxis? (0:26)
  2. What did the DISCOVER clinical trial teach us about the comparative efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate? (1:12)
  3. Could you tell us a little about the design of the open label phase of the study? (2:14)
  4. What have been the findings of this phase in terms of HIV infection, bone mineral density, renal biomarkers and body weight? (2:56)
  5. What are the clinical implications of these findings? (3:37)

Disclosures: Christoph Spinner reports grants, personal fees, non-financial support and other during the conduct of the study from Gilead Sciences, Janssen-Cilag, GSK/ViiV Healthcare, and MSD. Christoph Spinner also receives personal fees, non-financial support and other support outside the submitted work from AbbVie and Apeiron, personal fees from Formycon, and grants, personal fees and other from Eli Lilly.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch.

Filmed in coverage of IAS 2021 Virtual.

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