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Welcome to the latest edition of touchREVIEWS in Infectious Diseases, where we continue our mission to deliver insightful, cutting-edge perspectives in infectious disease diagnosis and management. This issue offers an array of topics spanning diagnostics, service delivery innovations and preventive care, reflecting the dynamic challenges and opportunities in our field. In our first editorial, Barbara […]

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FUTURE LEADERS: Curiosity, mentorship and purpose: Skye Opsteen on shaping a career in infectious disease

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Published Online: Mar 19th 2025

Skye Opsteen is a first-generation MD/PhD trainee in the Medical Scientist Training Program at the University of Alabama at Birmingham, Birmingham, AL, USA. Under the mentorship of Dr Nathan Erdmann, her PhD research explores the impact of chronic HIV infection on the manifestations and pathogenesis of long COVID. With a long-term goal of investigating infectious diseases from an immunologic perspective, Skye is also dedicated to advocating for individuals affected by healthcare disparities. Beyond research, she serves on the UAB Heersink School of Medicine admissions committee, mentors fellow medical students as a peer educator and works as a teaching assistant for an undergraduate course designed to introduce underrepresented students to medical and research career paths.

In this interview, she shares the moments that reinforced her dedication to her specialty, the invaluable lessons from mentors and advice for aspiring infectious disease researchers. She highlights the power of curiosity, mentorship and trusting one’s instincts in navigating the evolving landscape of infectious disease medicine.

Q1. What inspired you to pursue a career in infectious disease?
Two experiences propelled my interest in infectious disease research and my passion for helping populations plagued by healthcare disparities. The summer after my first year of college, I was accepted to an 8-week intensive program dedicated to basic cancer research and learning how to combat healthcare disparities. During the second half of my undergraduate experience, I had the opportunity to pursue a thesis project under the joint mentorship of Drs Sonya Heath and John Shacka, focused on delineating the predictive value of various immune markers in anticipating common comorbidities in people with HIV (PWH). These experiences profoundly changed my perspective on what my career could become and remain a motivation to this day.

 

Q2. Is there a particular moment or experience in your career that reinforced your passion for your specialty?
Any time I am given the opportunity to go to clinic and interact with patients directly, my passion for my research is reinforced. I really enjoy seeing the direct effects that my work ‘behind the scenes’ has on the patient population my work focuses on. Additionally, I was given the opportunity to attend the Conference on Retroviruses and Opportunistic Infections (CROI) for the first time in 2023 and was awarded a New Investigator Scholarship. Being immersed in HIV and SARS-CoV-2 research across the spectrum from basic science to clinical was eye opening and inspiring. As a New Investigator Scholar, I also had the opportunity to attend a small-group luncheon with Dr Anthony Fauci, who is a continuous inspiration.

 

Q3. What is the most valuable lesson a mentor has shared with you, and how has it influenced your work?
You can’t make a pros vs cons list for every career decision. It oftentimes comes down to your gut feeling on what path is right for you, and it’s okay if that isn’t the same path that you initially thought you’d be on or if it’s not the path your mentor advised you on. I’ve learned how to trust my gut more often when making tough decisions and have become okay with the unknowns for my career.

 

Q4. What advice would you offer to those just beginning their journey in infectious disease?
Stay curious and find a good mentorship team! Keeping that spark of curiosity as you delve deeper into the field helps you to continue advancing your work and staying content, even when there are setbacks. Additionally, having a strong mentorship team that advocates for you, your science, and your career is essential for advancing along your career path.

 
Disclosure: Skye Opsteen has no financial or non-financial conflicts of interest to declare in relation to this article.
Cite: FUTURE LEADERS: Curiosity, mentorship and purpose: Skye Opsteen on shaping a career in infectious disease. touchINFECTIOUS DISEASES. March 19th, 2025

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