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Foreword – touchREVIEWS in Infectious Diseases, Volume 3, Issue 1, 2024

Welcome to the latest edition of touchREVIEWS in Infectious Diseases, where we continue our mission to deliver insightful, cutting-edge perspectives in infectious disease diagnosis and management. This issue offers an array of topics spanning diagnostics, service delivery innovations and preventive care, reflecting the dynamic challenges and opportunities in our field. In our first editorial, Barbara […]

COVID-19

3 mins

Nagalingeswaran Kumarasamy, CROI 2022: Management and Treatment of COVID-19

Published Online: Mar 3rd 2022

Dr N Kumarasamy (Voluntary Health Services Hospital, Chennai, Southern India) joins us at CROI 2022, to discuss the potential tools available for the management and treatment of COVID-19.

The abstract entitled: ‘Phase III Trial of Molnupiravir in Adults with Mild Sars-Cov-2 Infection in India’ (Abstract #101) was presented at Conference on Retroviruses and Opportunistic Infections (CROI) 2022 (Virtual), 12-16 February 2022.

Question:

What tools are available for the management and treatment of COVID-19?

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch.

Filmed as a highlight of CROI 2022.

HIV vaccine advances: insights from CROI 2024

Barney Graham

HIV vaccine development harnesses breakthroughs in structure-based antigen design, sequencing, and single-cell analysis to create potent vaccines. Prof. Barney Graham, Professor of Medicine, Microbiology, Chemistry and Immunology, Morehouse School of Medicine in Atlanta, Georgia, USA explores advances reported at CROI 2024, emphasizing advances in targeting antibody lineages and augmenting CD8+ T cell responses, and highlighting sustaining funding models for HIV research and it's imperativeness for addressing broader public health issues.

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Pioneering HIV vaccine research through regional advances and vaccine equity

Barney Graham

HIV vaccine development, emphasizing HIV, RSV, and coronavirus COVID-19 research is discussed by Prof. Barney Graham. This information is crucial for immunologists, virologists, and those in vaccine research. Learn from cross-disciplinary strategies. You, as healthcare professionals in these fields, need to grasp these insights for innovation. HIV, RSV, and coronavirus studies offer valuable lessons. Keep up with the latest in vaccine technology.

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Evolving HIV diagnostic technologies: A new era of precision

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HIV diagnostic technologies are rapidly advancing, as Dr. Nitika Pai discussed, with self-tests and multiplex testing leading the way in accuracy and accessibility. The challenge remains in cost and strategic deployment. This field interests infectious disease specialists, clinical epidemiologists, and public health professionals. Stay informed on innovations like CRISPR and machine learning to enhance patient care. NAT (Nucleic Acid Test) costs and algorithmic bias in machine learning need attention for equitable access.

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HIV diagnostic innovations: revolutionizing the fight against HIV

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HIV diagnostics have transformed post-COVID, enhancing the acceptance and implementation of self-tests globally. Dr Nitika Pai, Division of Clinical Epidemiology, Experimental Medicine, Infectious Disease, McGill University, Montreal, Canada, discusses advancements in HIV diagnostics, especially self-testing, which has increased the acceptance and implementation of HIV self-tests globally.

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Molnupiravir, an oral antiviral against SARS-CoV-2: Chris Butler, ECCMID 2023

Molnupiravir, an oral antiviral against SARS-CoV-2 was first granted emergency use authorisation in 2021 to reduce the risk of hospitalisation and death in mild to moderate COVID-19 with increased risk of developing severe disease. We were delighted to speak with Prof. ...

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PANORAMIC trial - Molnupiravir efficacy in adults with COVID-19 at increased risk of adverse outcomes: Chris Butler, ECCMID 2023

PANORAMIC (ISRCTN30448031) was a multicentre, open-label, randomized controlled trial investigating novel treatments for COVID-19 in the UK. We were delighted to speak with Prof. Chris Butler (University of Oxford, Oxford, UK) to discuss the PANORAMIC study results, and how these ...

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COVID-19 vaccine development, updates and advances: Christoph Spinner, ECCMID 2023

The COVID-19 pandemic brought about the accelerated development of vaccinations to protect against variants of SARS-CoV-2, recently new targets of broad protection against potential future variants have been outlined and numerous vaccine candidates are in pre-clinical and clinical development. It ...

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Molnupiravir vs nirmatrelvir/ritonavir for COVID-19 in high-risk patients with haematological malignancy: Jon Salmanton-Garcia, ECCMID 2023

Molnupiravir is an oral antiviral medication that has shown to be effective in treating COVID-19. Nirmatrelvir/ritonavir is a combination of two drugs that have been granted emergency use authorization for the treatment of COVID-19. Dr Jon Salmanton-Garcia (University of ...

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MONET post hoc analysis comparing sotrovimab, tixagevimab/cilgavimab, and nirmatrelvir–ritonavir: Valentina Mazzotta, ECCMID 2023

The MONET phase 3 study investigated the safety and efficacy of several monoclonal antibodies (sotrovimab tixagevimab/cilgavimab, and nirmatrelvir–ritonavir) for the treatment of COVID-19 in non-hospitalised adult patients. We caught up with Dr. Valentina Mazzotta (IRCCS, Rome, Italy) to discuss ...

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VACCELERATE: a European network for the development of COVID-19 vaccine trials and beyond: Kerstin Albus, ECCMID 2023

VACCELERATE is a European network conducting COVID-19 vaccine trials, bringing together research from academic institutions all over Europe. In this touchINFECTIOUS DISEASES interview Dr Kerstin Albus (University of Cologne and University Hospital Cologne, Cologne, Germany) discusses how VACCELERATE aims to ...

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PHH-1V vaccine compared to BNT162b2 as a SARS-CoV-2 booster vaccine, phase IIb results: Patricia Muñoz García, ECCMID 2023

PHH-1V, a SARS-CoV-2 protein-based heterodimer vaccine was investigated in a phase IIb trial where the immunogenicity and safety of a heterologous booster with PHH-1V was assessed versus a homologous booster with BNT162b2 at 14, 28 and 98 days after vaccine ...

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Viki Male: COVID-19 and family planning - Impacts of vaccination and infection

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Viki Male: Navigating concerns about menstrual cycle changes after COVID-19 vaccination

The effects of COVID-19 vaccination on women's menstrual cycles have been a recent topic of interest and concern. Dr Victoria (Viki) Male (Imperial College London, London, UK) addresses that there have been some reported changes in women's menstrual cycles after ...

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Foreword – touchREVIEWS in Infectious Diseases, Volume 3, Issue 1, 2024

Conference Coverage

Learning Activities

Journals

Foreword – touchREVIEWS in Infectious Diseases, Volume 3, Issue 1, 2024

Nagalingeswaran Kumarasamy, CROI 2022: Management and Treatment of COVID-19

HIV vaccine advances: insights from CROI 2024

Pioneering HIV vaccine research through regional advances and vaccine equity

Evolving HIV diagnostic technologies: A new era of precision

HIV diagnostic innovations: revolutionizing the fight against HIV

Molnupiravir, an oral antiviral against SARS-CoV-2: Chris Butler, ECCMID 2023

PANORAMIC trial - Molnupiravir efficacy in adults with COVID-19 at increased risk of adverse outcomes: Chris Butler, ECCMID 2023

COVID-19 vaccine development, updates and advances: Christoph Spinner, ECCMID 2023

Molnupiravir vs nirmatrelvir/ritonavir for COVID-19 in high-risk patients with haematological malignancy: Jon Salmanton-Garcia, ECCMID 2023

MONET post hoc analysis comparing sotrovimab, tixagevimab/cilgavimab, and nirmatrelvir–ritonavir: Valentina Mazzotta, ECCMID 2023

VACCELERATE: a European network for the development of COVID-19 vaccine trials and beyond: Kerstin Albus, ECCMID 2023

PHH-1V vaccine compared to BNT162b2 as a SARS-CoV-2 booster vaccine, phase IIb results: Patricia Muñoz García, ECCMID 2023

Viki Male: COVID-19 and family planning - Impacts of vaccination and infection

Viki Male: Navigating concerns about menstrual cycle changes after COVID-19 vaccination

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