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It was a great pleasure to meet with Prof. Evangelos Giamarellos-Bourboulis (Attikon University Hospital, Athens, Greece) to discuss phase 3 SAVE-MORE study assessing the effect of anakinra for the treatment of patients with COVID-19 pneumonia.
Publication available to access here: https://www.nature.com/articles/s41591-021-01499-z
- Could you give us a brief overview of the role of the IL-1 pathways in the pathogenesis of COVID-19? (0:17)
- Following the results for canakinumab in COVID-19, what was the rationale for investigating anakinra in the treatment of severe COVID-19? (1:47)
- What were the aims and design of the SAVE-MORE study? (3:47)
- What were the findings of the study? (5:01)
- Based on these findings, where do you see anakinra sitting in the treatment paradigm for COVID-19 and which patients are most likely to benefit from its use? (6:46)
Disclosures: Evangelos Giamarellos-Bourboulis has nothing to disclose in relation to this video.
Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch.
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