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A double-stranded DNA virus of the Orthopoxvirus family, mpox (formerly monkeypox), continues to infect people daily, following the 2022 global outbreak.1 Two clades (clade 1 and clade 2) have been identified, with the 2022 outbreak caused by a subclade of clade 2, referred to as clade 2b.2 Comparatively, clade 1 leads to a more severe disease state and greater […]

Mahmoud Ghannoum, IDWeek 2021: Phase 3 Study Investigating Oteseconazole in the Treatment of Recurrent Vulvovaginal Candidiasis

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Published Online: Oct 15th 2021

It was a pleasure to meet with Prof. Mahmoud Ghannoum (Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA) to discuss a phase 3 study investigating oteseconazole in the treatment of recurrent vulvovaginal candidiasis.

The abstract entitled: ‘Susceptibility Testing of Oteseconazole (VT-1161) Against Clinical Isolates from Phase 3 Clinical Studies in Subjects with Recurrent Vulvovaginal Candidiasis‘ was presented at IDWeek 2021 (Virtual), 28 September – 3 October 2021.

Questions:

  1. What is the mechanism of action of oteseconazole? (0:05)
  2. What are the aims, and design of the phase 3 oteseconazole study? (1:05)
  3. What were the efficacy and safety findings of this study? (3:13)
  4. What questions remain unanswered about the use of oteseconazole in VVC and what future studies are planned? (5:26)

Disclosures: Mahmoud Ghannoum is contracted to conduct research from Mycovia pharmaceuticals, Scynexis, Amplyx Pharma, Gilead and Pfizer.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch.

Filmed as a highlight of IDWeek, Virtual 2021

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